Fosamax Issues and Treatments

Men and women alike are susceptible to osteoporosis.. Yet due to the decrease in estrogen production during the menopausal period of women, they are more affected. This reproductive hormone is vital in bone formation and bone remodeling. According to the World Health Organization, around 2.5 standard deviation DXA of bone mineral density (BMD) is found in every osteoporosis patient. There is no marked symptoms associated with this bone anomaly but there is an increase of bone breakage among osteoporosis patient. Specific types of medication such as biphosphonates and lifestyle changes are the common treatments for this kind of medical condition. The increase of Fosamax issues has made medical organizations to have a goal of reduced osteoporosis fractures by 20%. Heart attacks, strokes, and new breast cancer effects should be more dangerous than osteoporosis but statistics prove otherwise. A lot of money is also spent on this bone condition. And this will continue to rise as trends had shown.

A medical condition where degeneration of the bone occurs is called osteoporosis. Old age is seen as a culprit but it can still be caused by many other factors. Bones being brittle, porous, and prone to fracture are always the result.

Formulation of many osteoporosis treatments are being made in order to save any people. Lifestyle changes in diet, exercise and fracture risk prevention are the top treatments currently made for this medical condition. Yet, along with the previously noted lifestyle changes, biphosphonates, vitamin K, vitamin D, and calcium supplements, and estrogen.

The commonly prescribed drug for those who have osteoporosis is antiresorptive or bone anabolic agents such as biphosphonates. An example biphosphonate drug is Fosamax which is a medication normally prescribed to patients. Patients with osteoporosis who are using biphosphonate drugs for the first four years showed improvement in bone strengthening and risk prevention. However, reports from long-term Fosamax users of five years or more claim that the drug caused atypical, low-impact femur fractures, striking an additional blow to the accumulating lists of Fosamax adverse effects. And many people have now filed a Fosamax lawsuit because of these femur fractures.

Reference:

endocrineweb.com/conditions/osteoporosis/osteoporosis-drugs-medications

heraldonline.com/2011/11/15/3530056/leading-health-organizations-and.html

Taking Fosamax

An alendronate sodium called Fosamax has been the object of complaints due to its adverse effect, which put its reputation in a bad light. Its manufacturer has been facing cases one after another. For example, a consolidated Fosamax lawsuit is scheduled for trial in February which will take place in the Supreme Court of New Jersey. Now, it is imperative that we know how Fosamax works in the body so that we will better understand why adverse events like these lawsuits happen.

Fosamax belongs to the group of drugs known as bisphosphonate which makes the bones stronger. This class of drugs helps prevent the loss of bone mass. Their method of action makes them potent for treating bone diseases like osteoporosis for both men and women as well as Paget’s Disease.

Although it looks pretty stationary, our bones are actually in a constant process of replacing themselves, called bone remodeling cycle – bone cycle or bone metabolism – throughout our lifespan. This cycle consists of three phases: bone resorption, osteoclastic reversal and bone formation. Typically, bone cycle in human runs about three to six months.

In the bone resorption phase, a type of bone cells called osteoclasts break down bone tissues and release minerals like calcium into the blood. Moreover, osteoclastic reversal is the phase when the resorption process shifts to formative process. The last step of the cycle is the bone formation where there is the growth and development of bone tissues.

Bisphosphonates alter the bone cycle by hampering bone resorption, holding back bone loss. Minimizing the rate of bone thinning in people with osteoporosis aids in reducing the risk of bone fracture. The ultimate goal of treating osteoporosis is to prevent the occurrence to bone fractures.

However, there is mounting evidence that bisphosphonates, particularly Fosamax and its generic alendronate, may cause an unusual type of fracture in the thigh bone after using the drug for five years or so. There were some concerns that long-term bisphosphonates use can cause an over-suppression of bone turnover. Additionally, it is believed that minute cracks in the bone that were not able to heal well eventually mount up and cause this king of fracture.

Right now, the main goal is to prevent fractures from happening which is an adverse situation deemed rare. Many doctors have changed their prescription lengths of Fosamax to not more than three years as a response to these reports. Many of those who have suffered this type of Fosamax femur fracture have filed a Fosamax lawsuit already.

References:
http://www.medscape.com/viewarticle/405699_4
http://www.judiciary.state.nj.us/notices/2008/n081023b.pdf
http://www.judiciary.state.nj.us/notices/2008/n080716e.pdf

Read This Before Filing A Fosamax Lawsuit

Even before the Food and Drug Administration issued a post-marketing safety report requiring product labeling for bisphosphonates to reflect the risk of osteonecrosis of the jaw (ONJ), it is already publicly known thatmany people have been affected by the dangers associated with the medicine called Fosamax. Here, we can see that people were just reasonable when they filed for a Fosamax lawsuit. But we have to learn about things we must consider before we file for a lawsuit as a popular Fosamax Femur Fractures theory are facing challenges.

• Consult with a trusted physician. Most often, patients are not sure if Fosamax was really the cause of their injuries or if it injured them at all. A licensed and experienced physician is the best person to answer these important questions. She or he can advise their patients about continuing with their current Fosamax treatment or changing to an alternative therapy for osteoporosis.

• Collect records. Succeeding in a Fosamax femur lawsuit requires gathering the best evidence in order to prove that the drug caused actual harm. Patients should gather the following records: medical records; insurance documents including Medicare; a list of expenses; and employment records. These documents are necessary for proving "economic" losses before the court of law. Medical records provide documentation of any physical harm suffered from Fosamax intake. Insurance records show payment of treatment. Anything that does not appear in insurance forms, ranging from wheelchairs to costs of hiring a caregiver, can be found on a complete itemized list of expenses. Finally, loss of wages resulting from missed work can be shown to the court through employment records. The lack of these documents can be detrimental in efforts to prove the extent of injuries which could result in patients being denied any compensation.

• Keep a journal and save all forms of correspondence. Patients need to create a body of evidence to help the court decide what kind of compensation may be due to "non-economic" losses in a Fosamax femur lawsuit. Journal entries, correspondences to others through letters and e-mails, and even photographs showing the extent of injuries can prove to the court that a patient is entitled to damages for pain and suffering, scarring and disfigurement, and other non-economic losses.

• Avoid direct communication with Merck or any other drug developer. Fosamax femur lawsuits are adversarial processes by nature. The same can be said for negotiating any Fosamax settlement with Merck. Anything communicated to Merck or any other drug manufacturer can be used against the patient in any legal setting. It is in the best interest of the patient to consult a lawyer before signing any documents or communicating with Merck in any way

Determining how effective your Fosamax lawsuit depends on how affected parties take into account these important things.

References:

http://www.nejm.org/doi/full/10.1056/NEJMc1107029

http://www.ehow.com/list_6802382_reasons-medical-malpractice-claims.html

http://www.ehow.com/how_7765974_claim-accident-injuries.html

Paget’s Disease: Another Threat to your Bone Health

Fosamax has always been among the most widely used drugs in the United States over the years. But, if you look back and ahead at Fosamax lawsuits, you can tell that drug and its manufacturer, Merck,  also had their own share of bad times. This, and other drugs on the same classification are considered as the osteoporosis’ first line of treatment. Furthermore this drug may also be given to another serious health problem known as Paget’s disease.

Paget’s disease, also known to many as osteitis deformans, is the next most prevalent bone disease after osteoporosis in the United States. Added to that, it rarely occurs in people younger than 40 years old and its ratio from male to female is 1.2:1. Although it can exist in different areas in the world, it occurs largely in European countries such England, France and Germany.

Paget’s disease is a localized and chronic disorder that can result in enlarged and misshapen bones. In the initial phase of Paget’s disease, the bone remodeling cycle loses equilibrium where bone resorption becomes faster due to the increasing  number of bone cells responsible for breaking down the bones. It then proceeds to a stage with heightened bone formation causing bones that are larger but weaker than usual.

Paget’s disease can affect any bone in the skeleton but has affinity to the long bones, spine, skull and the pelvis. In most cases, this disease shows no symptoms at all making most of us unaware that we already have the bone disorder. Others may exhibit manifestations which depends on the afflicted bone of the disease. 

If left alone, this condition can lead to serious problems. For Instance, Paget’s disease with skull involvement can ultimately lead to the following problems:

•  Deafness
•  Vertigo
•  Tinnitus
•  Dental malocclusion
•  Basilar invagination
•  Cranial nerve disorders

Oftentimes patients diagnosed with Paget’s disease are treated with bone-strengthening drugs such as Fosamax or other bisphosphonates. However, there are findings suggesting that the use of Fosamax may put you at risk for serious problems including atypical fractures of the thigh bone. A significant number of people claiming to have been laid up by the long term effects of the drug are now determined to file a Fosamax lawsuit against Merck.

References:

http://en.wikipedia.org/wiki/Paget's_disease_of_bone

http://emedicine.medscape.com/article/334607-overview

http://www.rightdiagnosis.com/p/pagetbone/stats.htm

Osteoporosis Screening Methods Overview

With risk factors that encompasses everyone, nobody is safe from osteoporosis. Right now, more than 10 million Americans – both men and women – have already been afflicted with this major health problem and 34 million more at great risk. So that health plans will be initiated sooner, detecting the disease before it develops further is crucial.

There is much effort people exert in preventing or treating osteoporosis although some may not be very effective. For example, drugs like soy supplements that not diminish symptoms of osteoporosis are being included in their therapy since many believed they are beneficial.

To find out if you are likely to develop osteoporosis, your bone mineral density (BMD) is being computed. Diagnostics for osteoporosis are essential in your therapy and we have listed the most commonly used tools to make you familiar with those tests.

Dexa Scan (Dual X-ray Absorptiometry or DXA)

DXA is the most preferred technique to measure BMD. A DXA machine produces 2 x-ray beams with different energy levels – one beam has higher while the other has lower energy level. The thickness of the bone is determined by the amount of x-rays passing through the bones and from there the BMD can be measured.

Quantitative Computed Tomography

QCT bone densitometry uses high amount of exposure to radiation and costs a lot of money causing it to be unavailable for general clinical use. The method uses a CT scanner to get an accurate status of your bone. This 3-dimensional technique though is 2-3 times more sensitive than DXA making it the most accurate tool to measure bone density.

Ultrasonography

Quite a new diagnostic tool to determine your BMD, the ultrasound does not use radiation. The sonar beam is directed to a certain area where the scattering and the absorption of the waves will allow the assessment of BMD. This fairly new tool is still not as precise as the previous two techniques and perhaps more research are still being conducted about it.

Life with osteoporosis is never a joke. The throes of the disease itself are already an ordeal; and if you are taking bisphosphonates you might also be in agony with its adverse effects. For instance, some long-term Fosamax users claimed they have been harmed by the prolonged use of the drug which triggered them to file a Fosamax lawsuit against the maker of the drug.

References:

http://www.newportbodyscan.com/OsteoporosisFAQ%27s.htm#6

http://www.webmd.com/osteoporosis/guide/dexa-scan

How Sharon Wyatt’s Battle with Osteoporosis Ended with Jawbone Problems

Who could ever forget about Sharon Wyatt and the longest running soap opera in the American Television General Hospital? She played as Tiffany Hill Donely where she was active from June 1981 to July 10, 1984 and August 1986 to February 24, 1995 with reappearance in the 2008 season finale. Now that her part of the soap is done, she faces an entirely different challenge in her life – osteoporosis.

Sharon was diagnosed to have an early stage of osteoporosis way around four years ago. She was then prescribed with the bone-strengthening medication Fosamax which was made by Merck & Co. Fosamax is a bisphosphonate drug that is often prescribed for bone diseases such as osteoporosis and osteitis deformans (Paget’s disease).

Fearing that her condition could get worse, Sharon adhered strictly to her Fosamax therapy. Surprisingly, she suffered a severe adverse incident. According to her, “It was supposed to help [my] bones, but it made it worse.”

It was found that Sharon had an osteonecrosis of the jaw (ONJ). It’s a severe bone disease where a facial bone tissue necrotizes (dies) as a result of poor blood supply. 

The former General Hospital actress was nervous that ONJ would impinge on her career. “I’m afraid how it’s gonna affect my speaking.That’s death of an actor: If you can’t say the lines, you can’t work.” She already had a repair surgery for her ONJ last April 1.

As for now, Sharon is caring for her elderly mother in Tennesse. She needs to stay tough especially for her mother. "I told God I had about all I could handle and then this happens," she said."So I said, okay, fine, we'll get through this."

Bisphosphonates including Fosamax have been linked to ONJ. Merck allegedly failed to warn its patients about the said risk when taking the drug which might have made a significant decrease of the number of patients affected by the backlash.

Aside from ONJ, large studies have also noted the risk of suffering an unusual fracture on the femur bone after consuming the drug over a long duration. A number of patients have reported such incident claiming that their use of the drug has caused the damage. The other alternative treatment hormone therapy may also cause hip fracture when ceased according to a study – causing its patients to feel more dispirited.

Adverse Events Resulting from Fosamax Use

Even the biggest pharmaceutical corporations in the world like Merck & Co.also have their share of hard times. What’s in the news is that Merck & Co.is suspected of Illegal Marketing Practices with regard to some of its drugs. However, what really puts the company in a bad position is the several complaints from users about the adverse reactions caused by Fosamax, one of its biggest selling drugs.

In any given, Fosamax could be written in over 20 million prescriptions. Many have known this drug as alendronate, which is its generic form, and as the drug of choice for specific bone diseases like osteoporosis and Paget’s disease (osteitis deformans). It makes your bones strong by altering the cycle of bone remodeling particularly and prevent bone resorption.

However, there are mounting reports about the adverse effects that could result from the long term use of the drug. The most commonly reported cases were osteonecrosis of the jaw bone and an atypical fracture of the thigh bone. Moreover, the pharmaceutical company seemingly lacked the proper disclosure of the said hazards causing a number of its patronizers to take legal actions.

Around 2003 when one of the earliest Fosamax-related cases of ONJ was brought to the public. ONJ, also known by some as Bis-Phossy Jaw, is a serious bone disease where a bone tissue of the jawbone dies (necrotizes) due to inadequate supply of nutrition or blood. ONJ may present symptoms like pain upon chewing a gum and it usually detected during a dental check. 

On the other hand, a specific type of fracture has also been associated to the prolonged use of the drug. It was noted in large studies that women taking bisphosphonate drugs, a drug classification which includes Fosamax, have incurred a low-impact femur fracture. Yet, this repercussion Is considered uncommon and that the beneficial effects of the drug still supersedes.

So that the risks of these complications are reduced, some health care providers have decided to order Fosamax on a shorter duration. In most cases, they will tell their patients to temporarily hold Fosamax and other bisphosphonate drugs after 3 years of drug therapy. While the adverse and other side effects of Fosamax are alarming, the benefits of the drug still outweigh the associated risks. Talk to your doctor to know if the drug is right for you.

What Is Paget’s Disease And Why Is Fosamax The Treatment?

With the controversies of Fosamax still ringing in the ears of many, more people, even men are filing Fosamax femur fracture lawsuits. This medication is said to cause several adverse effects after a long-term use. The widely known osteoporosis medication is also approved by the Food and Drug Administration to treat this often overlooked bone disorder known as Paget’s disease.

Our bones go through a life-long process where mature bone tissues breakdown and are replaced with new bone tissues. With Paget’s disease of the bone, the breakdown and remodeling of the bone tissues becomes too excessive. The result of the process is misshapen, exaggerated but brittle and highly vascular bones.

Although the cause of Paget’s disease is unknown it is believed that it might be linked to the genetic composition or a viral infection in early life. The disease may only be in one or two areas of the skeleton, or throughout the body. The bones of the arm, the collar, the leg, the pelvis and the spine are the areas usually affected with the disease.

Most of the time, patients with Paget’s disease have mild or no symptoms at all. Often, symptoms are attributed with arthritis or other disorders. Symptoms may include:

• Bone pain – the most common symptom and usually occurs on the affected bone or the areas adjacent to the joints
• Enlarged head, headache and hearing loss especially if the skull is affected
• Bowing of the legs and other visible deformities
• Fracture especially on the long bones
• Joint pain or stiffness
• Neck pain
• Warmth of skin over the affected bone

Some cases do not need treatment. Most patients that are treated, however, are given drug therapy to help prevent further bone breakdown. Biphosphonates like Fosamax are presently the first-line of defense to help improve bone mineral density.

When treatment is given before major changes in the affected bones have occurred, the outlook is generally good. Possible complications of the disorder include bone deformities and fractures, deafness, paraplegia (paralysis of the lower extremities), and in rare occasions, a form of bone cancer known as osteogenic osteogenic sarcoma.

Fosamax is the drug of choice for Paget’s disease. Nonetheless, this drug should only be taken with your physician’s order to avoid any adverse events. Furthermore, if you suffered any harm due to long-term consumption of Fosamax, you may have a strong ground for filing a Fosamax lawsuit.

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• Fosamax and Its Dangers (ronaldredman.wordpress.com)

Fosamax Victims Can Afford to Pursue a Fosamax Femur Fracture Lawsuit

The femur is the largest and strongest single bone in the human body. A fracture of the femur will not only result in the most excruciating pain, but can also inhibit a person’s mobility. Patients that are experiencing these symptoms as a result of chronically taking the osteoporosis medication, Fosamax, may be interested in filing a Fosamax fracture lawsuit against the company that manufactures and distributes the drug, Merck. Concerns over potential hefty legal fees are alleviated with the fact that Fosamax femur fracture lawyers are not as expensive as previously thought.

A 2008 study by the Journal of Orthopedic Trauma has revealed evidence that long term use of Fosamax could lead to low impact femur fractures resulting from falls at standing height or less. This has led to an investigation by the U.S. Food and Drug Administration to find whether or not there is a direct causal relationship between Fosamax and femur fractures, which could ultimately result in a public recall and multiple Fosamax femur lawsuits.

Although a Fosamax recall has yet to be implemented, there is increasing evidence to encourage anyone who has suffered from a low impact femur fracture while taking the drug to begin preparing a case against Merck. Low impact fractures are not a common occurrence and the severity and unpredictability of these fractures should entitle victims of this drug to proper punitive damages from the pharmaceutical company distributing the drug.

Not all lawyers are necessarily expensive. It is unlikely that a Fosamax femur fracture lawyer will bill their clients at an hourly rate. Instead, a contingency fee arrangement will be made at the formation of the attorney-client relationship. This entails the attorney taking a percentage of the recovery, which is typically between a quarter to one third of the settlement, should the client win their Fosamax femur fracture lawsuit. However, should the client lose the case, they both receive nothing.

Fosamax femur fracture lawyers have made it affordable for victims to pursue a Fosamax femur lawsuit. Patients that have been affected by chronic Fosamax intake should get the reparations they are entitled to. Updated information about the Fosamax femur fracture lawsuit can be found on the website.